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TUBERCULOSIS

Tuberculosis is an infectious disease that is caused by bacteria called mycobacteria tuberculosis. It affects the lungs, central nervous system, lymphatic system, circulatory system, genitourinary system and the gastrointestinal system. It also affects the bones, joints, and even the skin at times. Symptoms  of tuberculosis  includes a chronic cough, blood in the phlegm, night sweats, fever, and unexplained weight loss. Tuberculosis is spread through the air, when people who are infected cough, spit or sneeze.

Tuberculosis has been around people and animals for at least 18,000 years. Scientists examining the entombed mummies of Egypt have found evidence of the disease in the spine remnants of some of the mummies, proving that these ancients Egyptians suffered from the disease while they were still alive. Scientists have also found strains of tuberculosis in the 18,000 year old remains of bison.

Scientists are not really sure  how tuberculosis has developed over the past millennia and debate whether  it first developed in cattle then spread to people, or if it started out in early humans and then spread to other animals. Tuberculosis was first identified as a contagious disease  by the  doctor Ibn Sina in the early part of the 11th century. Aside from writing “the Canon of Medicine” Sina alos help develop the method of quarantine to help stop the spread of tuberculosis and other contagious diseases. The mystery of the mycobacteria that causes tuberculosis was solved in part because of the work of Nobel award recipient Robert Koch who developed the staining method for microorganisms in 1882.

In order to diagnose tuberculosis, a doctor needs to perform a number of tests including a chest x-ray, tuberculin skin tests, blood tests as well as microscopic examination and microbiological cultures of body fluids. Once diagnosed, tuberculosis is treated with various antibiotics that are taken every day for six months or more. It is a long difficult process to rid someone of the disease making prevention through screening and vaccination the best defense.

Thanks, to a global vaccination effort, scientists once believed that tuberculosis was on its way to becoming completely eradicated. In 1913, for example, the number of tuberculosis cases in Great Britain was at 117,000 while the number dropped to 5,000 in 1987. However, recent trends have shown that tuberculosis is on the rise again with the number cases in Great Britain rising to 6,300 in 2000, then rising again in 2005 to 7,600.

Scientists cite several different causes for the rise of tuberculosis today. In the 1980’s the rise was accredited to the rise in HIV cases. Doctors also pointed to patients not sticking with their treatment regimens as another possible cause and people with tuberculosis entering going back out into public still coughing, spitting and sneezing out strains of the disease into the air. Another reason for the rise of tuberculosis in the new millennium is the development of drug resistant strains which stand up to the antibiotics that are used. These developments have made scientists skeptical as to whether or not it is actually possible to fully eradicate this disease form humankind.


FACTS ABOUT TUBERCULOSIS

What is tuberculosis?
Tuberculosis is a disease caused by a certain bacterium in the lungs. While it mostly affects the lungs, it can also affect the bones, kidneys and other organs.

How is it diagnosed?
Doctors are able to determine if a person has tuberculosis through a series of several tests. First, a PPD skin test is performed.PPD stands for Purified Protein Derivative and it is a test to see if you have had an immune response to the bacterium.  If this test comes out positive then there is a chance you have been infected. Then in order to find out if you are contagious, a thoracic X-Ray is done along with a physical exam.  Being PPD positive does necessarily mean that you are contagious.

Does being PPD positive mean that you are sick?
No, in fact post people who are PPD positive are not sick with tuberculosis. Testing positive means that bacterium is in the lungs but you are not yet affected by it. As long as the person’s immune system stays strong, tuberculosis will not manifest. However, if something causes the immune system to weaken, the bacterium might start to wake up.

How do you treat a tuberculosis infection?
The most common treatment involves taking a drug called isoniazid everyday at the same time for 6 months. A check up is also required once a month to make sure that there are no side effects from the isoniazid which has been known to cause nausea and a skin rash. If there is a side effect the doctor will then prescribe an alternative drug. The patient needs to strictly follow the regime prescribed by the doctor, otherwise the bacteria could continue to inhabit the lungs and cause harm. Since the side effects can interfere with the drugs efficacy, alcohol is strictly forbidden during treatment with isoniazid .

Does the tuberculosis then go away after 6 months of treatment?
If the patient follows the prescribed treatment, tuberculosis should then be eradicated from their body.  However, some strains of the bacteria have become resistant to treatment and remain in the lungs even after treatment.  Tests performed after the treatment will be able to determine whether the patient is now tuberculosis free of if further treatment is needed.

What are the symptoms of active tuberculosis?
Fever, loss of appetite, night sweats, loss of weight, intense coughs and fatigue are the most common symptoms.

How is active tuberculosis treated?
Treatment for active tuberculosis usually involves a combination of different drugs including isoniazid, rifampicin, ethambutol and pyrazinamide. Taking these drugs with alcojol or acetaminophen can cause side effects. Other side effects include nausea, vomiting, blurred vision, skin rash, skin rash, extreme fatigue, jaundice and fever.
 
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